Cyclosporine-A increases locomotor activity in rats with 6-hydroxydopamine-induced hemiparkinsonism : Relevance to neural transplantation. Commentary
Identifieur interne : 003F02 ( Main/Exploration ); précédent : 003F01; suivant : 003F03Cyclosporine-A increases locomotor activity in rats with 6-hydroxydopamine-induced hemiparkinsonism : Relevance to neural transplantation. Commentary
Auteurs : C. V. Borlongan [États-Unis] ; T. B. Freeman ; R. A. Hauser ; D. W. Cahill ; P. R. Sanberg ; R. R. TaskerSource :
- Surgical neurology [ 0090-3019 ] ; 1996.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
BACKGROUND The immunosuppressant cyclosporine-A (CsA) is the primary drug for neural transplantation in Parkinson's disease. However, little is known of its direct effects on movement disorders. Our previous observation of increased locomotor activity in normal rats injected with CsA prompted us to investigate further the effects of CsA on hemiparkinsonian rats. METHODS We examined the effects of CsA with 6-hydroxydopamine-induced hemiparkinsonism. The animals were randomly assigned to either intraperitoneal injections of CsA (15 mg/kg) or olive oil (the vehicle used for CsA) for 32 days. All animals were tested using the elevated body swing test, and the spontaneous and the amphetamine-induced rotational tests prior to and following the 32-day drug regimen. RESULTS As revealed by the elevated body swing test, CsA-treated rats had significantly higher mean percent contralateral (to the lesion) swings compared to their pretreatment level (p < 0.01) or to vehicle-treated rats at posttreatment (p < 0.005). In the spontaneous rotational test, CsA-treated rats displayed ipsilateral (to the lesion) rotations which were significantly higher than their pretreatment rotational behavior (p < 0.005) or the posttreatment rotational behavior of olive oil-treated rats (p < 0.0001). Similarly, CsA-treated rats displayed significantly more amphetamine-induced ipsilateral rotations compared to their or the olive oil-treated rats pretreatment level (p < 0.05). CONCLUSION Our present observations extend our previous findings on motor alterations produced by CsA on normal rats to hemiparkinsonian rats. These results taken together would suggest that CsA may interact with the locomotor effects observed following neural transplantation with adjunctive CsA immunosuppression.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Cyclosporine-A increases locomotor activity in rats with 6-hydroxydopamine-induced hemiparkinsonism : Relevance to neural transplantation. Commentary</title><author><name sortKey="Borlongan, C V" sort="Borlongan, C V" uniqKey="Borlongan C" first="C. V." last="Borlongan">C. V. Borlongan</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Neurological Surgery, Departments of Surgery, Neurology, Psychiatry, and Pharmacology, University of South Florida, College of Medicine</s1><s2>Tampa, Florida</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region><settlement type="city">Tampa</settlement></placeName><orgName type="university">Université de Floride du Sud</orgName></affiliation></author><author><name sortKey="Freeman, T B" sort="Freeman, T B" uniqKey="Freeman T" first="T. B." last="Freeman">T. B. Freeman</name></author><author><name sortKey="Hauser, R A" sort="Hauser, R A" uniqKey="Hauser R" first="R. A." last="Hauser">R. A. Hauser</name></author><author><name sortKey="Cahill, D W" sort="Cahill, D W" uniqKey="Cahill D" first="D. W." last="Cahill">D. W. Cahill</name></author><author><name sortKey="Sanberg, P R" sort="Sanberg, P R" uniqKey="Sanberg P" first="P. R." last="Sanberg">P. R. Sanberg</name></author><author><name sortKey="Tasker, R R" sort="Tasker, R R" uniqKey="Tasker R" first="R. R." last="Tasker">R. R. Tasker</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">96-0494030</idno><date when="1996">1996</date><idno type="stanalyst">PASCAL 96-0494030 INIST</idno><idno type="RBID">Pascal:96-0494030</idno><idno type="wicri:Area/PascalFrancis/Corpus">000F13</idno><idno type="wicri:Area/PascalFrancis/Curation">001010</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000E34</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000E34</idno><idno type="wicri:doubleKey">0090-3019:1996:Borlongan C:cyclosporine:a:increases</idno><idno type="wicri:Area/Main/Merge">004600</idno><idno type="wicri:Area/Main/Curation">003F02</idno><idno type="wicri:Area/Main/Exploration">003F02</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cyclosporine-A increases locomotor activity in rats with 6-hydroxydopamine-induced hemiparkinsonism : Relevance to neural transplantation. Commentary</title><author><name sortKey="Borlongan, C V" sort="Borlongan, C V" uniqKey="Borlongan C" first="C. V." last="Borlongan">C. V. Borlongan</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Neurological Surgery, Departments of Surgery, Neurology, Psychiatry, and Pharmacology, University of South Florida, College of Medicine</s1><s2>Tampa, Florida</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region><settlement type="city">Tampa</settlement></placeName><orgName type="university">Université de Floride du Sud</orgName></affiliation></author><author><name sortKey="Freeman, T B" sort="Freeman, T B" uniqKey="Freeman T" first="T. B." last="Freeman">T. B. Freeman</name></author><author><name sortKey="Hauser, R A" sort="Hauser, R A" uniqKey="Hauser R" first="R. A." last="Hauser">R. A. Hauser</name></author><author><name sortKey="Cahill, D W" sort="Cahill, D W" uniqKey="Cahill D" first="D. W." last="Cahill">D. W. Cahill</name></author><author><name sortKey="Sanberg, P R" sort="Sanberg, P R" uniqKey="Sanberg P" first="P. R." last="Sanberg">P. R. Sanberg</name></author><author><name sortKey="Tasker, R R" sort="Tasker, R R" uniqKey="Tasker R" first="R. R." last="Tasker">R. R. Tasker</name></author></analytic><series><title level="j" type="main">Surgical neurology</title><title level="j" type="abbreviated">Surg. neurol.</title><idno type="ISSN">0090-3019</idno><imprint><date when="1996">1996</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Surgical neurology</title><title level="j" type="abbreviated">Surg. neurol.</title><idno type="ISSN">0090-3019</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Animal model</term><term>Chemotherapy</term><term>Immunosuppressive agent</term><term>Parkinsonism</term><term>Rat</term><term>Treatment</term><term>Unilateral</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinsonisme</term><term>Unilatéral</term><term>Ciclosporine</term><term>Immunodépresseur</term><term>Modèle animal</term><term>Traitement</term><term>Animal</term><term>Rat</term><term>Chimiothérapie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND The immunosuppressant cyclosporine-A (CsA) is the primary drug for neural transplantation in Parkinson's disease. However, little is known of its direct effects on movement disorders. Our previous observation of increased locomotor activity in normal rats injected with CsA prompted us to investigate further the effects of CsA on hemiparkinsonian rats. METHODS We examined the effects of CsA with 6-hydroxydopamine-induced hemiparkinsonism. The animals were randomly assigned to either intraperitoneal injections of CsA (15 mg/kg) or olive oil (the vehicle used for CsA) for 32 days. All animals were tested using the elevated body swing test, and the spontaneous and the amphetamine-induced rotational tests prior to and following the 32-day drug regimen. RESULTS As revealed by the elevated body swing test, CsA-treated rats had significantly higher mean percent contralateral (to the lesion) swings compared to their pretreatment level (p < 0.01) or to vehicle-treated rats at posttreatment (p < 0.005). In the spontaneous rotational test, CsA-treated rats displayed ipsilateral (to the lesion) rotations which were significantly higher than their pretreatment rotational behavior (p < 0.005) or the posttreatment rotational behavior of olive oil-treated rats (p < 0.0001). Similarly, CsA-treated rats displayed significantly more amphetamine-induced ipsilateral rotations compared to their or the olive oil-treated rats pretreatment level (p < 0.05). CONCLUSION Our present observations extend our previous findings on motor alterations produced by CsA on normal rats to hemiparkinsonian rats. These results taken together would suggest that CsA may interact with the locomotor effects observed following neural transplantation with adjunctive CsA immunosuppression.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li></region><settlement><li>Tampa</li></settlement><orgName><li>Université de Floride du Sud</li></orgName></list><tree><noCountry><name sortKey="Cahill, D W" sort="Cahill, D W" uniqKey="Cahill D" first="D. W." last="Cahill">D. W. Cahill</name><name sortKey="Freeman, T B" sort="Freeman, T B" uniqKey="Freeman T" first="T. B." last="Freeman">T. B. Freeman</name><name sortKey="Hauser, R A" sort="Hauser, R A" uniqKey="Hauser R" first="R. A." last="Hauser">R. A. Hauser</name><name sortKey="Sanberg, P R" sort="Sanberg, P R" uniqKey="Sanberg P" first="P. R." last="Sanberg">P. R. Sanberg</name><name sortKey="Tasker, R R" sort="Tasker, R R" uniqKey="Tasker R" first="R. R." last="Tasker">R. R. Tasker</name></noCountry><country name="États-Unis"><region name="Floride"><name sortKey="Borlongan, C V" sort="Borlongan, C V" uniqKey="Borlongan C" first="C. V." last="Borlongan">C. V. Borlongan</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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